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ME/CFS Patients Show "Exhausted" Immune Systems in Landmark NIH Study

A significant NIH study reveals distinct immune and nervous system abnormalities in individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The research suggests that the immune system in ME/CFS patients may become "exhausted" after an infection, offering crucial insights into this debilitating condition.

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United States - Ekhbary News Agency

A groundbreaking study by the National Institutes of Health (NIH) has shed new light on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a severe multisystem disorder often triggered by infection. Published in Nature Communications, the research identified significant differences in the immune and nervous systems of ME/CFS patients, providing long-awaited physiological evidence for a condition often dismissed as psychosomatic. This comprehensive investigation focused on a carefully selected cohort, revealing that killer T cells—critical components of the immune response—exhibit markers of "exhaustion," indicating a compromised ability to combat persistent triggers.

The study observed reduced levels of CD226 and elevated PD1 protein in killer T cells from ME/CFS participants, suggesting the immune system effectively burns out and struggles to respond effectively. These findings are particularly pertinent given the parallels drawn between ME/CFS and Long COVID, highlighting the urgent need for better diagnostics and therapies. Experts speculate that lingering infection remnants or factors like a "leaky gut" could contribute to this immune exhaustion. This research marks a pivotal step towards validating the physiological basis of ME/CFS and fostering a deeper understanding of its complex mechanisms, offering hope for future treatments.

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